An Efficient Genome-Wide Multilocus Epistasis Search
نویسندگان
چکیده
منابع مشابه
Title : “ An efficient genome - wide multilocus epistasis search ”
High-throughput laboratory techniques are producing vast amount of genomic marker data – discretepredictors to association studies. Linear regression model is often considered to link study phenotypes andthese marker measurements to each other. Number of predictors in multi-marker regression models caneasily be much larger than number of observations. Therefore, one needs applic...
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Epistasis, a term coined by William Bateson in 1909 [1], refers to the interdependence of mutations in their phenotypic effects. Let the phenotypic value of a trait relative to that of the wild type be fA and fB for mutants A and B, respectively, and let the phenotypic value of the corresponding double mutant be fAB. Although variation exists, epistasis is usually defined by ε = fAB − fAfB and ...
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MOTIVATION Recent studies suggested that a combination of multiple single nucleotide polymorphisms (SNPs) could have more significant associations with a specific phenotype. However, to discover epistasis, the epistatic interactions of SNPs, in a large number of SNPs, is a computationally challenging task. We are, therefore, motivated to develop efficient and effective solutions for identifying...
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15 The potential for genome-wide modeling of epistasis has recently surfaced given the possibility of 16 sequencing densely sampled populations and the emerging families of statistical interaction models. 17 Direct coupling analysis (DCA) has earlier been shown to yield valuable predictions for single protein 18 structures, and has recently been extended to genome-wide analysis of bacteria, ide...
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OBJECTIVE AND METHODS This paper proposes an inegrative two-stage genome-wide search for pairwise epistasis on expression quantitative trait loci (eQTL). The traits are clustered into multi-trait complexes that account for correlations between them that may result from common epistasis effects. The search is done by first screening for epistatic regions and then using dense markers within the i...
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ژورنال
عنوان ژورنال: Genetics
سال: 2015
ISSN: 1943-2631
DOI: 10.1534/genetics.115.182444